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American businessman Jack Dwyer (Owen Wilson), wife Annie and their two young daughters arrive in Southeast Asia to begin a new life. As his company plans to improve the region's water quality, the family quickly learns that they're right in the middle of a political uprising. Armed rebels attack the hotel where they're staying, ordered to kill any foreigners that they encounter. Amid utter chaos, Jack must find a way to save himself and his loved ones from the violence erupting all around them.